Job Description

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We are currently seeking a highly motivated and passionate scientist to join our team in Immunology Discovery based in Cambridge MA. In this role, the candidate will collaborate with multiple cross-functional teams to advance portfolio projects, with a particular emphasis on supporting in vitro data generation. Responsibilities include performing and adapting cell-based in vitro protocols in a timely manner across diverse cell systems, data analysis and effective communication of results, and collaboration across multiple teams. The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research and early drug discovery. The position requires ability to work independently, demonstrate excellent technical, written and oral communication skills and work very well in a collaborative team environment.
Responsibilities:

• Human colon organoid culture, passaging, and plating for experiments to support the group.
• Perform cell-based assays using cell lines and mammalian primary cells.
• Test biologic and small molecules in cell-based assays for functional readouts including cell proliferation, cytokine release, and gene expression.
• Perform advanced molecular and cellular biology techniques (including but not limited to FACS, ELISA, MSD, HTRF, qPCR).
• Responsibilities may include processing animal tissue ex vivo and isolation of immune cells from human and animal tissue or blood.
• Work independently on the design, execution and interpretation of experimental results to validate hypotheses related to the project need.
• Maintain close communication with multiple groups to support human colon organoid cell needs.
• Implement and innovate new experimental protocols/techniques as needed.
• nalyse, interpret, document and report data consistently, concisely and rigorously, both to individual stakeholders and in group settings.
• Demonstrate scientific excellence through dedication to multiple projects in a fast-paced multi-disciplinary environment.
• Impact projects mostly through lab-based activities.

Requirements:

• The applicant must have a bachelor's degree in Biological Science or related field with 2+ years of experience in biotech or pharma setting (industry experience).
• Experience in in vitro cell culture (sterile techniques, handling challenging cell types) is required. Experience with cell-based assay development is a plus.
• Experience with primary epithelial cells and human colon organoids is required.
• Experience with immune cells including myeloid cells (monocytes macrophages or dendritic cells) is required.
• Experience in immunoassays including multi-colour flow cytometry and ELISA (or MSD, HTRF) is required.
• Experience with gene expression analysis by qPCR is required.
• Experience with ex vivo animal tissue processing is a plus.
• bility to learn new skills and apply them in a fast-paced research environment.
• Creativity, problem-solving, and attention to details.
• Excellent oral and written communication and collaboration skills.
• bility to work independently as well as in a team.
• Proven flexibility to deal with changing timelines and shifting work priorities.

Top Skills:

• Experience with human organoid culture.
• Experience with in vitro assays with primary human immune cells (ie myeloid, PBMCs).
• Experience with molecular and cellular analysis techniques including qPCR, MSD, ELISA, flow cytometry.
• Bachelor's degree in biology or related field.
• t least 2+ years' experience in industry or biotech setting.

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